Measurement of the distance of microfoci from a rectal gross tumor in a pathological specimen
10.3969/j.issn.1000-8179.2019.08.282
- VernacularTitle:直肠癌病理标本大体肿瘤周边微小癌灶距离的测定*
- Author:
Xujie BAO
1
;
Suyu ZHU
;
Xiaoyan CHEN
;
Ke LIU
;
Jumei ZHOU
;
Zheng WU
;
Yuanyuan LIU
Author Information
1. 南华大学研究生院(湖南省衡阳市421000)
- Keywords:
rectal cancer;
microfoci;
pathological specimen;
clinical target volume (CTV);
radiotherapy
- From:
Chinese Journal of Clinical Oncology
2019;46(8):406-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To measure the distance of the lateral, inferior, and superior microfoci from a gross tumor in a pathological speci-men and to provide scientific evidence for margin extension to form the clinical target volume (CTV) in high-dose radiotherapy for rec-tal cancer. Methods: Twenty-eight surgical specimens were collected from patients with rectal cancer who underwent total mesorectal excision (TME) in Hunan Cancer Hospital between October 2016 and April 2017. The nearest distance of the farthest peripheral micro-foci from the gross tumor was measured. The in vivo-in vitro tumor retraction factor (R1) was calculated by measuring the ratio of the tumor's perpendicular depth based on magnetic resonance imaging and immediate surgical specimens. The retraction factor (R2) in the process of pathological specimen makeup was calculated by knot labeling. The distance of microfoci extension was calculated based on that measured in pathological specimens including corrections with R1 and R2 and record as microcarcinoma extension mea-sured in vivo,MEin vivo. Results: Among the 28 pathological specimens, lateral, inferior, and superior microfoci were found in 17 (60.7%), 3 (10.7%), and 0 cases, respectively. The mean R1 was 0.913 and mean R2 was 0.803. The farthest distance measured inferiorly was 28 mm in vivo after correction. The maximum, minimum, and mean measured lateral distances were 12.03 mm, 3.03 mm, and 7.50 mm after correction, respectively. The 95% frequency value was within 10 mm. Conclusions: The lateral microfoci extension was within 10 mm for 95% of the rectal cancer patients. The margin expansion to form the CTV was suggested to be 10 mm for a late-course boost of high-dose radiotherapy for rectal cancer.
