Clinical features and prognosis of intracranial embryonal tumors in children
10.3969/j.issn.1000-8179.2019.07.110
- VernacularTitle:儿童颅内幕上胚胎性肿瘤的治疗及预后分析
- Author:
Dongliang HOU
1
;
Tong FANG
;
Linan SONG
;
Baojin SUN
;
Li CHEN
;
Hui YANG
;
Bo LIU
Author Information
1. 首都医科大学附属北京世纪坛医院放疗科(北京市100038
- Keywords:
embryonal tumor;
clinical features,prognosis
- From:
Chinese Journal of Clinical Oncology
2019;46(7):342-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical features and prognosis of intracranial embryonal tumors in children. Methods: Clinical data of 27 patients with intracranial embryonal tumors who were admitted to Beijing Shijitan Hospital, Capital Medical University be-tween May 2011 and December 2018 were retrospectively analyzed. Results: The study included 27 patients, comprising 17 male and 10 female children, with a median age of 7 years. Twelve patients underwent gross total resection, and 15 patients underwent subto-tal resection. After surgery, all 27 patients underwent craniospinal irradiation. The dose of craniospinal irradiation was 27-30.6 Gy, and the dose of the tumor bed was 55.8-60 Gy. Twenty-two patients underwent chemotherapy regimen composed of irinotecan, vtncris-tine, etoposide, nedaplatin after radiotherapy. The median follow-up period was 22 (4-93) months. Nine patients are alive without lo-cal or distant recurrence. Eighteen patients died; the causes of death were intracranial recurrence and spinal cord metastasis. The 1-, 3-, and 5-year survival rates were 79.4%, 50.2%, and 36.5%, respectively. Conclusions: Intracranial embryonal tumors in children are rare and malignant and can metastasize along the neuroaxis. Surgery, adjuvant radiotherapy, and chemotherapy are important for pa-tients with intracranial embryonal tumors. Moreover, the prognosis is poor.
