Investigation of clinicopathological features and indication of endoscopic resection in young patients with intramucosal early gastric cancer
10.3969/j.issn.1000-8179.2019.06.127
- VernacularTitle:黏膜内早期胃癌青年患者临床病理特征及内镜下治疗适应证的探讨*
- Author:
Yuan SHENG
1
;
Yetao WANG
;
Fei YE
;
Kaiguang ZHANG
Author Information
1. 中国科技大学附属第一医院(安徽省立医院)消化内科(合肥市230001
- Keywords:
young population;
stomach neoplasm;
early stage;
intramucosal carcinoma;
endoscopic submucosal dissection (ESD);
lymph node metastasis
- From:
Chinese Journal of Clinical Oncology
2019;46(6):284-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate clinicopathological features, risk of lymph node metastasis, and indications of endoscopic submu-cosal dissection (ESD) in young patients with intramucosal early gastric cancer (EGC). Methods: In total, 325 EGC patients who under-went radical gastrectomy and had complete clinicopathological data in Anhui Provincial Hospital from March 2009 to December 2016 were retrospectively evaluated. All patients were confirmed to have intramucosal cancer based on their postoperative pathology re-sults. The patients were assigned into two groups according to their age: young group (≤40 years) and old group (>40 years). The clini-copathological features and safety of ESD in the youth group were analyzed. Results: Among all patients with intramucosal EGC, 30 (9.2%) were in the youth group. Intramucosal cancer in the youth group occurred predominantly in women, and the pathological types were mainly undifferentiated and mixed, which were more likely to metastasize to the lymph nodes. In the youth group, EGC patients with intramucosal differentiated type, who had ESD indications, had no risk of lymph node metastasis. However, the rate of lymph node metastasis was up to 25% in intramucosal undifferentiated-type EGC patients who had expanded ESD indications. Conclusions:Young patients with intramucosal EGC have poor pathological differentiation and strong invasiveness, and ESD may be considered for the treatment of differentiated intramucosal cancer.
