Application of mRNA in tumor immunotherapy
10.3969/j.issn.1000-8179.2019.03.246
- VernacularTitle:mRNA疗法在肿瘤免疫治疗中的应用
- Author:
Yanping PAN
1
;
Hao ZHANG
;
Hong XIANG
;
Xiaohu YANG
;
Yong HU
Author Information
1. 中国科学院深圳先进技术研究院
- Keywords:
mRNA;
tumor vaccine;
tumor immunotherapy;
clinical application
- From:
Chinese Journal of Clinical Oncology
2019;46(3):154-158
- CountryChina
- Language:Chinese
-
Abstract:
mRNA therapy, which involves the use of mRNAs as drugs for disease treatment, is a new kind of gene therapy. It can either treat diseases caused by gene deficiency or repair tissue through the expression of functional proteins, or be applied to immunothera-py through the expression of antigens, antibodies, or receptors, and is thus, of great value for various clinical applications. In tumor im-munotherapy, mRNA that encodes tumor-related antigens, or specific antigens, antibodies, or receptors enters the cytoplasm and is translated into proteins, which then induce specific immune responses, thereby enabling disease prevention and treatment. With the development of immunotherapy and mRNA technologies, mRNA therapy for malignant tumors and infectious diseases has entered the stage of clinical applications. This review briefly introduces the synthesis, purification, and modification of mRNA, with emphasis on mRNA-based tumor immunotherapy, clinical trial results, and key opportunities and challenges in the development of new drugs.
