Research advances of chromosomal 8q24 aberrance in breast cancer
10.3969/j.issn.1000-8179.2019.03.157
- VernacularTitle:染色体8q24区域异常在乳腺癌中的研究进展
- Author:
Hongqin JIA
1
;
Shuai LI
;
Yunwei HAN
;
Fangfang LIU
;
Weidong LI
;
Li FU
Author Information
1. 天津医科大学肿瘤医院乳腺病理科
- Keywords:
breast cancer;
8q24;
amplification;
single nucleotide polymorphism
- From:
Chinese Journal of Clinical Oncology
2019;46(3):150-153
- CountryChina
- Language:Chinese
-
Abstract:
With the development and application of microarray and high-throughput sequencing technology, it is possible to genomi-cally scan breast cancer associated CNV and SNPs. Multiple researches showed that the frequent aberrance of 8q24 was associated with breast cancer. Oncogenes such as MYC, PSCA and breast cancer associated loci are located in 8q24, and frequent amplification of 8q24 was proposed to be related with breast cancer development and prognosis. This review summarizes the association of the 8q24 amplification and SNPs with breast cancer by correlated genes on this locus.
