Analysis of survival and prognostic factors of patients with intracranial ependymoma
10.3969/j.issn.1000-8179.2019.03.157
- VernacularTitle:影响颅内室管膜瘤患者生存和预后的相关因素分析
- Author:
Yiying BIAN
1
;
Weipeng CHEN
;
Zhanzhan LI
;
Ying WANG
;
Lei HUO
;
Rui WEI
;
Liangfang SHEN
;
Jidong HONG
Author Information
1. 中南大学湘雅医院肿瘤科(长沙市410008)
- Keywords:
ependymoma;
survival;
prognosis;
related factors
- From:
Chinese Journal of Clinical Oncology
2019;46(3):138-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the factors affecting the survival and prognosis of patients with intracranial ependymoma. Methods:From January 2008 to January 2018, the prognoses of 276 patients with intracranial ependymoma were analyzed using Log-rank and Cox model analysis. The variables included sex, age, tumor location, tumor diameter, resection extent, pathological grade, Ki-67 index, postoperative radiotherapy, and postoperative chemotherapy. Results: Tumor location, resection extent, and postoperative radiothera-py could all affect the overall survival (OS) and progression-free survival (PFS) of patients with intracranial ependymoma (P<0.001) and independently affected the OS (P<0.001, P<0.001, and P=0.002, respectively) and PFS (P<0.001, P<0.001, and P=0.001, respectively). The Ki-67 index was an independent factor affecting PFS in patients with intracranial ependymoma (P<0.001). The supratentorial loca-tion and Ki-67 index≥10% were independent risk factors indicating poor prognosis (P<0.001). Total resection and postoperative radio-therapy were protective factors (P<0.001 and P=0.001, respectively). Conclusions: Tumor location, resection extent, Ki-67 index, and postoperative radiotherapy are independent factors affecting the prognosis of intracranial ependymoma. It is helpful to extend the PFS and OS of patients through complete tumor resection or postoperative radiotherapy.
