Advances in the clinical applications of large panel high-throughput sequencing in tu-mors
10.3969/j.issn.1000-8179.2019.02.329
- VernacularTitle:肿瘤大基因包高通量测序在临床中的应用进展
- Author:
Yanan CHENG
1
;
Jinpu YU
Author Information
1. 天津医科大学肿瘤医院肿瘤分子诊断中心
- Keywords:
high-throughput sequencing;
large panel;
immunotherapy;
targeted therapy;
tumor mutation burden
- From:
Chinese Journal of Clinical Oncology
2019;46(2):94-98
- CountryChina
- Language:Chinese
-
Abstract:
With the advancement of high-throughput sequencing technology, improvements in big data processing and analysis have been witnessed. Evaluation of anti-tumor effects of targeted therapy and immunotherapy using various molecular markers based on high-throughput sequencing and big data are moving towards clinical application. Panel detection of different genetic markers pro-vides the basis for cancer diagnosis and treatment. In this article, the classification of high-throughput sequencing panel, application of large panel in cancer diagnosis, targeted therapy, immunotherapy, and the problems encountered in the clinical application of large panels are reviewed in order to provide a reference for their clinical application and promote the advancement of precision medicine.
