Research progress in the molecular epidemiology of gastric cancer
10.3969/j.issn.1000-8179.2019.01.911
- VernacularTitle:胃癌分子流行病学研究进展
- Author:
Sha HUANG
1
;
Jin DAI
;
Juanjuan GAO
;
Weicheng YOU
;
Kaifeng PAN
;
Wenqing LI
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所流行病学研究室
- Keywords:
gastric cancer;
biomarkers;
molecular epidemiology
- From:
Chinese Journal of Clinical Oncology
2019;46(1):16-21
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is a malignant tumor characterized by high morbidity and mortality. With the development of molecular biol-ogy technology and the emergence of various new omics detection techniques in recent years, molecular epidemiologists of gastric cancer have conducted extensive studies on the genetic and host factors, as well as gene-environment interactions associated with ex-posure to environmental factors in gastric cancer. In addition, epidemiologists have studied the evolution of precancerous gastric le-sions, the development of gastric cancer, and explored relevant biomarkers to provide major evidence for the prevention and control of gastric cancer. This review summarizes the latest advances in the molecular epidemiology of gastric cancer, including existing evi-dence in studies for candidate-approach-based serum/plasma biomarkers, genome-wide association, whole-exome sequencing, tissue microarrays, as well as studies on metabolomics and microbiomes. We expect to provide insights into the future of molecular epidemi-ology studies in gastric cancer, promoting etiologic research, and the precise prevention and control of gastric cancer.
