Advances in epigenetic research on soft tissue sarcomas

VernacularTitle:软组织肉瘤表观遗传学研究进展*
Author: Jinming ZHANG ¹ ; Xiaotong MA ; Helin FENG
Author Information

1. 河北医科大学第四医院骨科(石家庄市050011
Keywords: sarcoma; epigenetics; soft tissue
From: Chinese Journal of Clinical Oncology 2018;45(24):1277-1281
CountryChina
Language:Chinese
Abstract: Soft tissue sarcomas (STSs) are malignant tumors originating from mesenchymal tissues. They have lower morbidity rates than other cancers, which is only about 1% among adult malignancies. STSs consist of several subtypes and many of them are highly malignant. The 5-year survival rate is approximately 50%-60%. Investigation of STS pathogenesis demonstrated that epigenetic chang-es were closely related to the occurrence and development of STSs. Different from genetics changes, epigenetic changes are heritable and occur mainly through DNA methylation, histone modification, non-coding RNA regulation, and chromatin remodeling, all of which occur without changing the DNA sequence. Elucidation of the epigenetic mechanisms involved in STSs can help develop new clinical di-agnosis and treatment methods, and this article aims to review the recent advances in epigenetic research on STS.