Clinical analysis of hypersensitivity reactions to oxaliplatin
10.3969/j.issn.1000-8179.2018.24.141
- VernacularTitle:奥沙利铂过敏反应临床特征的研究*
- Author:
Xiaoqian LI
1
;
Quanliang YANG
;
Guangzhao HE
;
Yanzhi BI
;
Chengliang ZHANG
;
Jian MA
Author Information
1. 苏州大学附属常州肿瘤医院肿瘤内科(江苏省常州市213000)
- Keywords:
colorectal cancer;
oxaliplatin;
hypersensitivity reaction
- From:
Chinese Journal of Clinical Oncology
2018;45(24):1268-1271
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the clinical characteristics of allergic reactions in patients with colorectal cancer after routine premed-ication with dexamethasone (5 mg) before chemotherapy with an oxaliplatin-containing regimen and to provide a reference for reduc-ing the risk of oxaliplatin allergy. Methods: Retrospective analysis of 242 patients with colorectal cancer who received chemotherapy with an oxaliplatin-containing regimen at the Changzhou Cancer Hospital of Soochow University from January 2014 to October 2017 was performed, and the incidence of allergic reactions was calculated. The associations between multiple factors and allergic reactions were then assessed using univariate analysis. The independent factors of allergic reactions were assessed using multivariate Logistic analysis, and the treatment outcome of oxaliplatin rechallenge in allergic patients was discussed. Results: A total of 242 patients were studied. They received routine premedication with dexamethasone (5 mg) before chemotherapy with an oxaliplatin-containing regi-men. Twelve (4.9%) patients had type I allergic reactions, with a median onset time of 6 (5.5-10.5) cycles and a median cumulative dose of 895 (716.5-1 075.0) mg. Multivariate analysis identified undergoing an oxaliplatin-free interval as an independent risk factor (P=0.04). Rechallenging patients with prophylactic agents was successful in 1 (33.3%) of 3 patients who completed their treatment. Conclusions: Routine low-dose dexamethasone premedication before oxaliplatin administration is safe and exhibited a lower inci-dence of hypersensitivity reactions than that reported in literature. An oxaliplatin-free interval may increase the risk of hypersensitivity reactions. Caution should be exercised while rechallenging allergic patients with oxaliplatin.
