Research progress of cardiotoxicity induced by chemotherapeutic drugs
10.3969/j.issn.1000-8179.2018.24.174
- VernacularTitle:化疗药物所致心脏毒性的研究进展*
- Author:
Yongfei ZHANG
1
;
Jiuwei CUI
Author Information
1. 吉林大学第一医院肿瘤中心(长春市130021
- Keywords:
tumor;
chemotherapy;
anthracycyclines;
cardiotoxicity
- From:
Chinese Journal of Clinical Oncology
2018;45(24):1243-1247
- CountryChina
- Language:Chinese
-
Abstract:
Following the development of antineoplastic modalities and improvement in the prognosis of patients with cancer, the oc-currence of cardiotoxicity induced by chemotherapeutic drugs is increasing. Traditional chemotherapeutic drugs, mainly anthracyclines cause varying degrees of direct or indirect damage to the heart, which may even occur several years after the end of treatment. This is-sue is becoming more complicated with the emergence of some new antineoplastic drugs. Treatment options for patients with cancer are limited, and these also have an important effect on patient survival and prognosis. Cardio-oncology is a emerging discipline that in-volves understanding the pathophysiology of cardiotoxicity induced by chemotherapeutic drugs, evaluation of the risks, early detec-tion and systematic management, and optimal drug therapy to reduce the occurrence of cardiotoxicity and to improve the prognosis of patients.
