Progress in Gene Therapy of Hereditary Neurological Ion Channel Disease
10.3760/cma.j.issn.1008?6315.2019.04.020
- VernacularTitle:遗传性神经系统离子通道病基因治疗的研究进展
- Author:
Xiaoyi WANG
1
;
Wenna SU
;
Tiankuo XUE
;
Yulan ZHU
Author Information
1. 哈尔滨医科大学第二附属医院神经内科 150081
- Keywords:
Ion channel disease;
Gene therapy;
Gene therapy;
Gene editing;
CRISPR／Cas9
- From:
Clinical Medicine of China
2019;35(4):382-385
- CountryChina
- Language:Chinese
-
Abstract:
Current therapies for hereditary neuropathy are often difficult to control or have low patient tolerance,so it is imperative to explore new therapies??Gene therapy has been shown that in many studies it may be applied to nervous system diseases and may become an effective treatment for hereditary nervous system ion channel diseases in the future??At the same time,the continuous progress of photogenetics, chemical genetics and gene editing technology also provides a good basis for the development of gene therapy for hereditary neuropathy??We will review the methods, mechanisms, transduction vectors, promoters and administration routes of gene therapy for hereditary neurological ion channel disease??
