Doxorubicin-eluting beads vs conventional TACE for hepatocellular carcinoma: a Meta-analysis
10.3969/j.issn.1005-202X.2019.02.022
- VernacularTitle:阿霉素洗脱微球TACE对比传统TACE治疗肝癌的Meta分析
- Author:
Zhaiwen ZHOU
1
;
Ziyu WANG
;
Qinlian CHEN
;
Junhai HUANG
Author Information
1. 广州中医药大学第一附属医院放射科
- Keywords:
hepatocellular carcinoma;
drug-eluting bead transarterial chemoembolization;
Meta-analysis;
therapeutic efficacy
- From:
Chinese Journal of Medical Physics
2019;36(2):239-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a Meta-analysis for assessing the therapeutic efficacy and safety of doxorubicin-eluting bead transcatheter arterial chemoembolization (DEB-TACE) vs conventional TACE (C-TACE) in the treatment of hepatoeellular carcinoma (HCC).Methods The relevant studies on DEB-TACE and C-TACE for HCC were searched from PubMed,Web of Science and CK1N databases.The tumor responds and adverse events in the selected studies were analyzed with RevMan5.0 statistical software.Moreover,publication bias was assessed by a funnel plot.Results Thirteen studies with 1 325 HCC patients were finally included in this analysis.The tumor response to DEB-TACE was better than that to C-TACE (OR:2.28;95％CI [1.75,2.96];P＜0.001 0).The risk of adverse events in DEB-TACE group was also lower than that in C-TACE group (RR:0.56;95％ CI [0.32,0.97];P=0.04).Conclusion Compared with C-TACE,DEB-TACE is more effective and has lower risk of adverse events in the treatment of HCC.
