Research progress in neurokinin-1 receptor antagonist aprepitant used for postoperative nausea and vomiting

VernacularTitle:神经激肽-1受体拮抗药阿瑞匹坦用于术后恶心呕吐的研究进展
Author: Yun LI ¹ ; Yi SUN ; Xizhe ZHANG ; Qi ZHOU
Author Information

1. 内蒙古赤峰市医院麻醉科 024000
Keywords: Aprepitant; Neurokinin-1 receptor antagonists; Postoperative nausea and vomiting; Review
From: Journal of Chinese Physician 2019;21(7):1112-1115
CountryChina
Language:Chinese
Abstract: Postoperative nausea and vomiting ( PONV) is a common complication after anaesthesia, which hinders the rapid recovery of patients. Aprepitant, one of neurokinin-1 (NK-1) receptor antagonists is mainly used to prevent nausea and vomiting by blocking the binding of substance P to NK-1 receptor. It has the advantages of high selectivity, strong affinity and long half-life, and its new antiemetic target pro-vides a new choice for prophylactic treatment of PONV. This article summarize studies on the prophylaxis of aprepitant in treatment of PONV.