Relationship between blood lipid level and Parkinson's Disease:A Meta-analysis
10.3760/cma.j.issn.1008-1372.2019.07.015
- VernacularTitle:血脂水平与帕金森病相关性的Meta分析
- Author:
Fanxi XU
1
;
Hainan ZHANG
;
Chunyu WANG
;
Lixia QIN
;
Yun CHEN
Author Information
1. 中南大学湘雅二医院神经内科
- Keywords:
Cholesterol;
Triglycerides;
Parkinson disease;
Meta-analysis
- From:
Journal of Chinese Physician
2019;21(7):1024-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective Although multiple lines of evidence suggested that serum lipid is related to Parkinson's disease ( PD) , it has been controversial. The aim of this study is to conduct a systematic review and meta-analysis to analyse the relationship between serum lipid levels and PD risk. Methods Pertinent studies were identified by a search in Pubmed, Medline, Web of Science, Cochrane Library, Wanfang data-base, the Wiper database and China National Knowledge Infrastructure (CNKI) up to July, 2018. All sta-tistical analyses were conducted using STATA version 12. 0. Results Eleven related articles met our selec-tion criteria and a total of 1424 PD patients and 7250 healthy controls were included in further analysis. Through meta-analysis, low triglyceride ( TG) level appeared to increase risk of developing PD [ standard-ised mean difference (SMD) = -0. 31, 95％ CI ( -0. 40, -0. 21), P=0. 318, I2 =14. 7％], while no significant association was identified between total cholesterol ( TC) [ SMD= -0. 09, 95％ CI ( -0. 40, 0. 22), P=0. 000, I2 =94. 0％], low density lipoprotein cholesterol (LDL-C) [SMD= -0. 10, 95％ CI ( -0. 40, 0. 19), P=0. 000, I2 =92. 3％] and high density lipoprotein cholesterol (HDL-C) [SMD=-0. 09, 95％ CI ( -0. 22, 0. 05), P=0. 103, I2 =45. 5％] with PD. The similar conclusion was ob-tained by subgroup analysis in both Asian and non-Asian. Conclusions Our results indicate that TG were associated with the risk of PD, while TC, LDL-C and HDL-C maybe not associated with the risk of PD. However, this conclusion needs further confirmation.
