Research progress on prevention and treatment of ischemia-reperfusion injury in intestinal transplantation
10.3760/cma.j.issn.1008-1372.2019.05.046
- VernacularTitle:小肠移植缺血再灌注损伤的防治研究进展
- Author:
Min XU
1
;
Tao YANG
;
Kewei MENG
;
Chong WANG
Author Information
1. 天津医科大学一中心临床学院 300192
- Keywords:
Intestine,small;
Organ transplantation;
Reperfusion injury;
Ischemic preconditioning;
Review
- From:
Journal of Chinese Physician
2019;21(5):791-794
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal transplantation is the only treatment option for irreversible intestinal failure and parenteral nutrition failure.Although the progress of immunosuppressive therapy and the improvement of surgical techniques have improved the prognosis of intestinal transplantation,it is still unsatisfactory compared with other solid organ transplantation,mainly due to the fact that the intestinal mucosa is susceptible to damage due to ischemia.The basic pathophysiological process of ischemia-reperfusion injury(IRI) is that ischemia/reperfusion induces the production of reactive oxygen species (ROS),inflammation and cell apoptosis,leading to tissue damage.In recent years,the pathophysiology of ischemia-reperfusion injury in intestinal transplantation has made some new progress,providing more possibilities for the prevention and treatment of intestinal transplantation IRI.Although most of them are animal experimental results,they have important reference value for clinical application.
