Study on relationship between blood cell parameters and lower extremity atherosclerotic disease in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1008-1372.2019.05.014
- VernacularTitle:伴下肢动脉病变的2型糖尿病患者血细胞相关参数的研究
- Author:
Yuhong LI
1
;
Zhenqian FAN
;
Shuang SHAO
;
Jianchao GUO
Author Information
1. 天津医科大学第二医院内分泌科 300211
- Keywords:
Diabetes mellitus,type 2;
Lower extremity;
Peripheral arterial disease;
Atherosclerosis;
Hematologic tests
- From:
Journal of Chinese Physician
2019;21(5):696-699
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variations and clinical significance of mean platelet volume (MPV),platelet distribution width (PDW) and red cell distribution width (RDW) in type 2 diabetic patients with lower extremity atherosclerotic disease (LEAD).Methods In this study,330 patients (168 male and 162 female ones) diagnosed with type 2 diabetes mellitus were recruited.According to the ankle brachial index (ABI),all the patients were divided into three groups:patients without LEAD (Group A),patients with mild to moderate LEDA (group B),and severe LEAD (group C).And 100 healthy subjects served as control group.Blood routine,fasting plasma glucose (FPG),Hemoglobulin Alc (HbAlc),blood pressure,high-sensitivity C-reactive protein (hs-CRP),blood lipids,serum creatinine and uric acid were all measured in the patients.Results MPV,PDW,RDW in all the patients with type 2 diabetes mellitus were significantly higher than those in the control group (P ＜ 0.05).Compared with the group without LEAD,MPV,PDW and RDW in the group with LEAD were significantly higher,with significant statistically difference (P ＜ 0.05).Pearson correlation analysis showed that MPV,PDW,RDW were positively correlated with the index of blood glucose and lipids.Logistic regression analyses indicated that the levels of MPV,PDW,RDW,hsCRP,HbAlc and low-density lipoprotein cholesterol (LDL-C) were significantly associated with lower extremity arterial disease in type 2 diabetes mellitus.Conclusions Patients with higher MPV,PDW and RDW levels were more likely to develop LEAD than those with lower levels.MPV,PDW and RDW were important risk factors for lower extremity atherosclerotic disease in patients with type 2 diabetes mellitus.
