The correlation of whole brain apparent diffusion coefficient with neurological impairment, Hcy metabolism and oxygen free radical generation in patients with Alzheimer's Disease
10.3760/cma.j.issn.1008-1372.2019.05.007
- VernacularTitle:阿尔茨海默病患者全脑表观扩散系数与神经功能损害、Hcy代谢、氧自由基生成的相关性
- Author:
Jianghong LIU
1
;
Liyan QIAO
;
Li WANG
;
Yi ZHAI
;
Lichun ZHANG
;
Lehong GAO
Author Information
1. 首都医科大学宣武医院神经内科
- Keywords:
Alzheimer disease;
Diffusion tensor imaging;
Cognitive dysfunction;
Homocysteine;
Reactive oxygen species
- From:
Journal of Chinese Physician
2019;21(5):665-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of whole brain apparent diffusion coefficient (ADC) with neurological impairment,homocysteine (Hcy) metabolism and oxygen free radical generation in patients with Alzheimer's disease (AD).Methods The patients diagnosed as AD in Xuanwu Hospital of Capital Medical University from March 2014 to December 2017 were selected as AD group and healthy persons as control group.The ADC of whole brain was calculated after magnetic resonance scanning.The degree of neurological impairment was evaluated by Montreal Cognitive Function Assessment Scale (MoCA).The levels of Hcy metabolic index and oxygen free radical production were measured after collecting serum.Results ADC values of AD group in parietal lobe,frontal lobe,temporal lobe and occipital lobe were not significantly different from those of control group (P ＞ 0.05).The ADC value of hippocampus as well as serum Hcy,malondialdehyde (MDA) and nitric oxide (NO) contents were significantly higher than those of control group,while MoCA score as well as folic acid (FA),vitamin B12 (VitB12),superoxide dismutase (SOD) and glutathione peroxidase (GSH) contents in serum were significantly lower than those of control group (P ＜ 0.05);ADC value of hippocampus in AD patients was negatively correlated with MoCA score as well as serum FA,VitB12,SOD and GSH contents,and positively correlated with serum Hcy,MDA and NO contents.Conclusions The increased ADC value of hippocampus in AD patients was related to the cognitive function injury,Hcy metabolism disorder and excessive generation of oxygen free radicals.
