Signaling pathways and neural circuits of alcohol reward memory
10.3760/cma.j.issn.1674-6554.2019.08.018
- VernacularTitle:酒精奖赏记忆的信号通路和神经环路
- Author:
Shuai YU
1
;
Chuansheng WANG
;
Ruiling ZHANG
;
Yahui XU
Author Information
1. 新乡医学院第二附属医院睡眠医学科 453002
- Keywords:
Alcohol dependence;
Reward memory;
Protein kinase
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(8):764-768
- CountryChina
- Language:Chinese
-
Abstract:
A key symptom of alcohol dependence is the strong desire to consume alcohol,which of-ten leads individuals to relapse despite negative social,interpersonal and health consequences. Core of crav-ing is repeatedly drinking alcohol and relevant cues can form pathological reward memory,which is the root cause of craving and relapse. Therefore,the extinction of the alcohol related reward memory is important for reducing relapse. The establishment of alcohol reward memories is associated with reward,motivation and memory circuits in the brain. Dysregulation of alcohol reward memory pathways is a key factor in the devel-opment of alcohol dependence, and the nature of these pathways varies depending on the brain region in which they are located. So systematic review that what reward memory pathways are involved in the develop-ment of alcohol dependence,and what brain regions are involved in these pathways,combined with animal ex-periments and alcohol dependent magnetic resonance imaging data,explain how alcohol reward memory signa-ling pathways regulate alcohol reward memory and how these pathways interact with neural circuits,plays a key role in the early recognition,prevention and treatment of alcohol dependence.
