Correlation analysis of single nucleotide polymorphism of ABCG1 gene and cerebral infarction in Li nationality of Hainan province
10.3760/cma.j.issn.1674-6554.2019.08.007
- VernacularTitle:ABCG1基因单核苷酸多态性与海南黎族动脉粥样硬化性脑梗死的关联性分析
- Author:
Hui WANG
1
;
Zhilu LI
;
Yong ZHANG
;
Yunxia ZHANG
Author Information
1. 海南省干部疗养院(海南省老年病医院)
- Keywords:
Single nucleotide polymorphism;
Haplotype;
Cerebral infarction;
ATP binding box transporter G1
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(8):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between three single nucleotide polymorphisms of ABCG1 gene ( rs4148102,rs225445 and rs183436) and cerebral infarction of Li nationality in Hainan. Methods Totally 236 cases ( case group) of patients with cerebral infarction and 144 healthy controls (control group) of Li nationality who were treated in a hospital in Hainan province from January 2015 to June 2018 were selected. Genomic DNA from peripheral blood of patients in the two groups was extracted and gen-otype analysis was conducted using flight mass spectrometry. Snapstatus analysis software was used to analyze the association between haplotype and cerebral infarction,and Hardy-Weinberg equilibrium verification was performed. SPSS25. 0 was used to analyze the difference in genotype distribution and allele distribution. Re-sults The distribution frequencies of GG, AG, AA genotypes of rs4148102 in the case group ( 62. 7%, 25. 9%,11. 4%) and the control group(521. %,38. 2%,9. 7%) were significantly different (P<0. 05),and the occurrence frequencies of GG in the control group were significantly lower than those in the case group. The occurrence frequencies of TT,CT and CC of rs225445 were also statistically different between the two groups(36. 9%,41. 1%,22. 0% in case group,48. 6%,38. 2%,13. 2% in control group),and the occur-rence frequencies of CC in the control group was significantly lower than that in the case group. There were statistically significant differences in the frequencies of allele T and C of rs225445 and allele C and A of rs183436 between the two groups (P<0. 05). Conclusion Genotype GG of rs4148102 and genotype CC of rs225445 may be the susceptible factors of cerebral infarction in Li nationality in Hainan province.
