Effect of high-definition transcranial direct current stimulation on visual spatial working memory in patients with schizophrenia
10.3760/cma.j.issn.1674-6554.2019.08.006
- VernacularTitle:高精度经颅直流电刺激对精神分裂症患者视空间工作记忆的影响
- Author:
Feifei XU
1
;
Kongliang HE
;
Lu WANG
;
Xingui CHEN
;
Xiaoling WU
;
Guixian XIAO
;
Kai WANG
Author Information
1. 安徽医科大学安徽省精神医学中心
- Keywords:
Transcranial direct current stimulation;
Working memory;
Schizophrenia
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(8):699-704
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of high-definition transcranial direct current stimula-tion on visual spatial working memory in patients with schizophrenia. Methods Sixty-six patients with schizophrenia were enrolled in a randomized,double-blind,placebo-controlled study. The subjects were ran-domized into a true stimulation group of 33 patients and a placebo control group of 33 patients,each patient only received one stimulation. After receiving a stimulus,the left dorsolateral prefrontal lobe was stimulated by high-precision transcranial direct current. The true stimulation group was stimulated with a current of 1. 5 mA for 20 min. The control group used pseudo-stimulation,and only the current was passed within 30 s of the beginning and the end of the stimulation. Both groups completed the neuropsychological background test and the n-back task before stimulation,and the stimulation was performed after five days. After the stimula-tion,the two groups completed the n-back task again,and compared the Changes in grades to reflect changes in working memory before and after the pseudo-stimulation. Results Before the stimulation,the response rate of the 3-back task was compared with that of the control group ((0. 32±0. 21),(0. 32±0. 22)),the true stimulation group ((0. 28 ± 0. 19), ( 0. 35 ± 0. 21)), and the difference was statistically significant ( F=5. 298,P=0. 025). Conclusion Using high-definition transcranial direct current stimulation to stimulate the left dorsolateral prefrontal cortex using can improve the visual memory function of patients. In the future,this technique can be applied to the cognitive promotion of memory impairment in patients with schizophrenia.
