Study on the level of peripheral serum glial-derived neurotrophic factor in children with attention deficit hyperactivity disorder
10.3760/cma.j.issn.1674-6554.2019.08.004
- VernacularTitle:注意缺陷多动障碍患儿外周血清胶质源性神经营养因子水平的研究
- Author:
Na LIU
1
;
Yan SANG
;
Shengzhi CHEN
;
Xiaoming LIU
Author Information
1. 徐州医科大学附属徐州儿童医院神经内科 221002
- Keywords:
Attention deficit hyperactivity disorder;
Glial-derived neurotrophic factor;
Children
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(8):689-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of peripheral serum glial-derived neurotrophic factor (GDNF) levels in children with attention deficit hyperactivity disorder(ADHD),and to provide a new mark-er for early identification of ADHD in clinical practice. Methods Totally 42 drug-naive children with ADHD(ADHD group) and 45 healthy children(HC group) were included. General demographic informa-tion,scale scores,and fasting peripheral serum GDNF levels were compared between the two groups. Mean-while,the correlation between GDNF level and symptom severity score of children with ADHD was analyzed. Results There were significant differences in FSIQ,attention deficit, and hyperactivity/impulsivity scores between ADHD group and HC group(FSIQ(105. 26±13. 82) vs (114. 73±9. 93); attention deficit(23. 60± 5. 06) vs (20. 04±2. 85); hyperactivity/impulsivity(19. 43±3. 47) vs (15. 93±2. 42),all P<0. 05). Serum level of GDNF in the ADHD patients was significant lower than that in the HC group ((442. 52± 70. 01) pg/ml vs (554. 02±101. 37)pg/ml,P<0. 01). In addition,GDNF levels were negatively correlated with at-tention deficit scores in children with ADHD (radj=-0. 447,P<0. 01). More importantly,ROC curve results show that GDNF had good diagnostic value (AUC=0. 81). Conclusion GDNF levels decreased child with ADHD. Decreased serum GDNF levels have certain promising value in the diagnosis of ADHD.
