Association study of MTHFR C677T polymorphism and birth body mass with risk of autism
10.3760/cma.j.issn.1674-6554.2019.08.001
- VernacularTitle:孤独症患儿亚甲基四氢叶酸还原酶基因C677T多态性、出生体质量与患病风险的关联研究
- Author:
Jishui ZHANG
1
,
2
;
Fang WANG
;
Yi SU
;
Han LU
;
Tian ZHANG
;
Lifang WANG
;
Shaomei SHANG
;
Weihua YUE
Author Information
1. 首都医科大学附属北京儿童医院精神科 100045
2. 国家儿童医学中心
- Keywords:
Autism;
MTHFR gene;
Birth body mass;
Risk of disease
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(8):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of MTHFR C677T polymorphism and birth body mass with the vulnerability of autism in Chinese Han population. Methods Totally 1 505 children with au-tism have been recruited,using the diagnosis and statistical manual,4th revised version ( DSM-IV-R) diag-nostic criteria for autism. And 1 308 healthy control subjects sex matched with the children with autism were enrolled for the study. All the participants were identified the birth body mass ( kg) according to the birth medical recording. All the subjects were examined the MTHFR C677T genotypes,using the polymerase chain reaction- restrict fragment length polymorphism (PCR-RFLP) methods. The frequencies of genotypes,alleles and birth body mass were compared between autism and healthy control groups using the chi-square and other tests. Results The MTHFR C677T (P=0. 004,OR=1. 18,95% CI=1. 02-1. 29),low birth body mass (<2. 5 kg) (P=0. 001,OR=1. 04,95%CI=1. 02-1. 06),and their interactive effects ( P=0. 0001,OR=2. 18,95%CI=1. 44-3. 32) were associated with the vulnerability of autism. Conclusions The MTHFR C677T polymorphism,low birth body mass and their interactive effects might be associated with susceptibility of autism in Chinese Han population.
