Study on serum level of HTR1A promoter methylation in manic episode of bipolar disorder type Ⅰ
10. 3760/cma. j. issn. 1674-6554. 2019. 05. 006
- VernacularTitle:双相Ⅰ型障碍患者躁狂发作期血清HTR1A基因启动子区甲基化水平的研究
- Author:
Qifeng DU
1
;
Cunyou ZHAO
;
Yan YU
;
Baoguo DU
;
Daiwei ZHANG
;
Yanzhen REN
;
Shufen LI
;
Ting-Yun JIANG
;
Yihua CHEN
Author Information
1. 中山市第三人民医院危机干预科 528451
- Keywords:
Bipolar disorder;
Epigenetics;
DNA methylation
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(5):412-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the methylation level of 5-hydroxytryptamine receptor 1A(HTR1A) gene promoter region and severity of symptom in the manic epi-sode patients with bipolar disorder type Ⅰ(BD-Ⅰ). Methods Fifty six manic episode patients with BD-Ⅰand fifty nine healthy controls were randomly included in the study. The level of HTR1A gene promoter meth-ylation was measured with pyrosequencing technique in both manic episode patients with BD-Ⅰ and the healthy controls. The severity of symptoms was assessed with score of Bech-Rafaelsen Mania Rating Scale (BRMS) in patients with BD-Ⅰ. Pearson correlation analysis was employed to explore the correlation be-tween the serum level of HTR1A promoter methylation and score of BRMS in BD-Ⅰgroup. Results In-creased serum level of HTR1A gene promoter methylation was found in manic episode patients with BD-Ⅰ((66. 55±10. 55)%) compared with that in healthy controls((54. 03±8. 85)%)(P<0. 01). Positive corre-lation was found between the serum level of HTR1A gene promoter methylation and total score of BRMS in manic patient with BD-Ⅰ(r=0. 534,P<0. 01). Conclusion The current findings suggest that the serum level of HTR1A gene promoter methylation can be an epigenetic indicator for severity of manic symptom in BD-Ⅰ.
