Ketamine exhibit antidepressant effect through regulating sleep-wake rhythm and synaptic homeosta-sis
10. 3760/cma. j. issn. 1674-6554. 2019. 03. 018
- VernacularTitle:氯胺酮调控睡眠节律和突触内稳态的抗抑郁效应机制
- Author:
Chuanjun ZHUO
1
,
2
;
Hongjun TIAN
;
Li ZHANG
;
Meng LI
;
Walter MARTIN
;
Gais STEFFEN
Author Information
1. 天津医科大学精神医学系 300070
2. 南开大学附属天津市安定医院精神科 300222
- Keywords:
Ketamine;
Sustained antidepressant effect;
Homer1a protein;
Synaptic pruning;
Brain network
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(3):285-289
- CountryChina
- Language:Chinese
-
Abstract:
A single infusion of ketamine has sustained antidepressant effects and significantly de-creases the risk of suicide,and the effects can last up for 7-10 days,but the underlying mechanism is un-clear. The mechanism was reviewed underlying the antidepressant effects of ketamine,and found that ket-amine may exert its antidepressant effect by regulating sleep/wake cycle,synaptic pruning,molecular path-ways,and neural circuits for treatment-refractory depression. Further studies are needed to investigate the ge-netic,molecular mechanisms underlying the sustained antidepressant effect of ketamine,and the associated imaging findings through in vivo imaging of animals and imaging genetics techniques,explore the optimal time for administration of ketamine,and then provide accurate scientific basis for enhancing its anti-depressant effect.
