Research progress on metabolic reprogramming of innate immune cells involved in immune-regulation of sepsis
10.3760/cma.j.issn.2095-4352.2019.07.023
- VernacularTitle:固有免疫细胞代谢重编程调控脓毒症免疫稳态的研究进展
- Author:
Lujing SHAO
1
;
Chunxia WANG
;
Yucai ZHANG
Author Information
1. 上海交通大学附属儿童医院重症医学科
- Keywords:
Sepsis;
Innate immunity;
Metabolic reprogramming;
Immunosuppression
- From:
Chinese Critical Care Medicine
2019;31(7):910-912
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppression plays a critical role in death of sepsis. Innate immunity is the first line defense to prevent pathogen invasion, and neutrophils, macrophages, dendritic cells and natural killer cells (NK cells) are closely involved in the process of the immune-regulation during sepsis. Recently, metabolic reprogramming in immune cells is known as a keystone for immune intervention therapy in sepsis. Here, we focus on the recent advances in metabolic regulation in neutrophils, macrophages, dendritic cells and NK cells including glycolysis, fatty acid synthesis, fatty acid oxidation and arginine metabolism involved in the immune-regulation of sepsis. This review will be helpful to summarize the mechanisms underlying sepsis-induced immunosuppression.
