Non aromatic hydrocarbon receptor dependent regulatory mechanism of cytochrome P4501A1 and its role in infection and inflammation
10.3760/cma.j.issn.2095-4352.2019.06.023
- VernacularTitle:细胞色素P4501A1的非芳香烃受体依赖调控机制及其在感染和炎症中作用的研究进展
- Author:
Xin TANG
1
;
Tao CHEN
;
Lixing TIAN
;
Xingyu WANG
;
Kuan LIU
;
Qi HUANG
;
Huaping LIANG
Author Information
1. 遵义医科大学附属医院重症医学科
- Keywords:
Cytochrome P450;
Regulatory mechanism;
Infection;
Inflammation
- From:
Chinese Critical Care Medicine
2019;31(6):777-780
- CountryChina
- Language:Chinese
-
Abstract:
Infectious and inflammatory diseases are important diseases threatening human health. Without timely control, a series of complications will occur in patients, such as sepsis, inflammatory factor storm, and even lead to death. It has been found that cytochrome P4501A1 (CYP1A1) plays a key role in the development of infectious and inflammatory diseases through aromatic hydrocarbon receptor (AhR) dependent and non-dependent pathways in different cells and organs induced by different substances. The non AhR dependent regulatory mechanism of CYP1A1 and the different roles of CYP1A1 in infection and inflammation is reviewed in order to provide reference for further research on the relationship between CYP1A1 and infection and inflammation.
