Research progress on the mechanism of 5-hydroxytryptamine in sepsis

VernacularTitle:5-羟色胺在脓毒症中作用机制的研究进展
Author: Zhuanhuan DU ¹ ; Li MA ; Lingling ZHEN ; Mengjiao SUN ; Xiaorong DONG ; Hong AN
Author Information

1. 兰州大学第二医院急危重症科
Keywords: Sepsis; 5-hydroxytryptamine; 5-hydroxytryptamine transporter; Selective serotonin reuptake inhibitor
From: Chinese Critical Care Medicine 2019;31(5):662-664
CountryChina
Language:Chinese
Abstract: Sepsis has the characteristics of high morbidity and high mortality, which is the main cause of death in critically ill patients. Peripheral 5-hydroxytryptamine (5-HT) is mainly synthesized and secreted by enterochromaffin cells and plays a role in the development and progression of inflammation. This article focuses on 5-HT, 5-HT transporter (SERT) and selective serotonin reuptake inhibitors (SSRIs) in immune response, inflammatory factor release, oxidative stress, intestinal bacterial translocation and microcirculation of sepsis. The role of the review is to find new ideas for the clinical treatment of sepsis.