Possible protective role of melatonin on heat stress induced apoptosis
10.3760/cma.j.issn.2095-4352.2019.05.028
- VernacularTitle:褪黑素在热打击诱导细胞凋亡中可能的保护作用
- Author:
Jian GONG
1
;
Zhengtao GU
;
Lei SU
Author Information
1. 深圳市龙岗区第三人民医院重症医学科
- Keywords:
Heat stress;
Heat stroke;
Melatonin;
Apoptosis;
Endoplasmic reticulum stress;
Mitochondria
- From:
Chinese Critical Care Medicine
2019;31(5):658-661
- CountryChina
- Language:Chinese
-
Abstract:
During the onset of heat stroke, heat is the most fundamental cause of injury. It has been demonstrated in a number of animal and cell experiments that hyperthermia can directly induce tissue damage and cell death, and cells can activate apoptotic signals or direct necrosis depending on the extent of heat stress. In general, high heat stress activates apoptotic signals and induce apoptosis. Therefore, the form of damage of tissue cells during the onset of heat stroke is currently considered to be mainly apoptosis. In recent years, it has been found that the heat stress molecular biology research regulates the physiological activities of cells in a wide range and participates in the intracellular signal transduction process. Melatonin and its metabolites are broad-spectrum antioxidants and free radical scavengers that regulate a variety of molecular pathways, such as inflammation, proliferation, apoptosis, and metastasis, under different pathophysiological conditions. This article summarized the research on the effects of melatonin and heat shock on apoptosis, and evaluated the possible protective effects of melatonin on the pathogenesis of heat stroke, and provided new therapeutic ideas for the clinic.
