Clinical value of non-coding RNA molecular markers for sepsis
10.3760/cma.j.issn.2095-4352.2019.05.026
- VernacularTitle:非编码RNA分子标志物对脓毒症临床价值的研究进展
- Author:
Jiaojiao YUAN
1
;
Min LI
;
Xueni CHANG
;
Yu CHEN
;
Chenming DONG
Author Information
1. 兰州大学第二医院重症医学科
- Keywords:
Sepsis;
Non-coding RNA;
MicroRNA;
Long-chain non-coding RNA;
Circular non-coding RNA;
Molecular marker
- From:
Chinese Critical Care Medicine
2019;31(5):650-653
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis and septic shock are important clinical problems in critically ill patients, accounting for the first cause of death in intensive care unit (ICU). Therefore, early diagnosis and treatment are particularly important. Recently, genome-wide expression analysis of non-coding RNA in septic patients showed that more than 80% were differentially expressed compared with healthy individuals. These molecules play important roles in biological processes, including innate immunity, mitochondrial function and apoptosis. Therefore, a class of non-coding RNAs such as microRNA (miRNA), long-chain non-coding RNA (lncRNA) and circular non-coding RNA (circRNA) are increasingly recognized as a regulator of various signaling pathways. The potential of regulatory non-coding RNA target to treat sepsis was discussed by studying non-coding RNAs that might serve as molecular markers of sepsis, and its clinical value was evaluated.
