Role of Ca2+ in hypoxic pulmonary vasoconstriction
10.3760/cma.j.issn.2095-4352.2019.05.025
- VernacularTitle:Ca2+在低氧性肺血管收缩中的作用
- Author:
Guanping WEI
1
;
Yuan CHENG
;
Yu HUANG
;
Qing HE
Author Information
1. 西南交通大学
- Keywords:
Hypoxic pulmonary vasoconstriction;
Hypoxic pulmonary hypertension;
Pulmonary artery smooth muscle cell;
Transient receptor potential channel;
Voltage operated calcium channel;
Store operated calcium channel;
Receptor operated calcium channel
- From:
Chinese Critical Care Medicine
2019;31(5):647-649
- CountryChina
- Language:Chinese
-
Abstract:
In acute hypoxia, pulmonary vascular will contract and divert blood to better ventilated area to optimize ventilation/perfusion matching, which is known as hypoxic pulmonary vasoconstriction (HPV). In chronic hypoxia, irreversible pulmonary vascular remodeling can be induced, characterized by pulmonary artery middle smooth muscle cells and the outer fiber cell hyperplasia in luminal stenosis and pulmonary artery hypertension (PAH) eventually. Furthermore, PAH can cause increased ventricular afterload, and right heart failure in severe cases. Pulmonary artery smooth muscle cell (PASMC) elevated Ca2+ concentration is one of the most important factors of its contractions, proliferation and migration. Recent studies on Ca2+ promoting in HPV were summarized in order to provide evidence for clinical prevention of hypoxia and therapeutic PAH.
