A Case of Cerebral Toxoplasmosis Following Tandem Autologous Stem Cell Transplantation in a Multiple Myeloma Patient.
- Author:
Kye Hyung KIM
1
;
Kyoung Ho SONG
;
Jae Hyun JEON
;
Wan Beom PARK
;
Sang Won PARK
;
Hong Bin KIM
;
Nam Joong KIM
;
Inho KIM
;
Myoung don OH
Author Information
- Publication Type:Case Report
- Keywords: Toxoplasmosis; Cerebral; Stem cell transplantation; Autologous; Multiple myeloma
- MeSH: Arm; Biopsy; Brain; Brain Stem; Cerebrum; Diagnosis, Differential; Edema; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Leg; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Myeloma; Neurologic Manifestations; Pyrimethamine; Stem Cell Transplantation; Stem Cells; Sulfadiazine; Toxoplasma; Toxoplasmosis; Toxoplasmosis, Cerebral; Trimethoprim, Sulfamethoxazole Drug Combination
- From:Infection and Chemotherapy 2010;42(3):181-186
- CountryRepublic of Korea
- Language:English
- Abstract: Toxoplasmosis is a rare but fatal complication in hematopoietic stem cell transplant recipients, usually associated with allogeneic hematopoietic stem cell transplantation (HSCT). We report a case of cerebral toxoplasmosis in a patient with multiple myeloma, following tandem autologous stem cell transplantation. A 55-year-old Korean male presented with weakness in both legs that had progressed to both arms. A magnetic resonance imaging scan of the brain revealed multiple, variable-sized ring-enhancing lesions with surrounding edema in the cerebral hemispheres and brain stem. Stereotactic biopsy revealed bradyzoites of Toxoplasma gondii in the brain tissue. The patient received trimethoprim-sulfamethoxazole, followed by pyrimethamine and sulfadiazine, accompanying treatment for progressive multiple myeloma. Cerebral toxoplasmosis should be considered as one of the differential diagnoses in patients with neurologic signs following autologous HSCT.
