Clinical progress of vasopressin in the treatment of septic shock

VernacularTitle:血管加压素治疗感染性休克的临床进展
Author: Lei LIU ¹ ; Ruiqiang ZHENG ; Qihong CHEN
Author Information

1. 大连医科大学
Keywords: Septic shock; Vasopressin; Hydrocortisone; Withdrawal; Adverse effect
From: Chinese Critical Care Medicine 2019;31(4):501-504
CountryChina
Language:Chinese
Abstract: Septic shock is a serious stage of sepsis with a hospital mortality rate of more than 40%. The pathophysiology of septic shock is vasodilation and increased permeability. Fluid resuscitation, vasopressor drugs are usually used to maintain the perfusion pressure of the main organs. However, infectious patients usually have the irresponsive vessel to catecholamines and may lead to obvious side effects using high doses of norepinephrine or dopamine. Recent studies have shown that vasopressin (AVP) improves hemodynamics, increases tissue perfusion, and synergizes with norepinephrine in patients with septic shock, showing extent application prospects in the treatment of septic shock. The practice of AVP in septic shock is reviewed in this article in order to provide a reference for clinicians.