Research progress of pyroptosis in sepsis
10.3760/cma.j.issn.2095-4352.2019.04.026
- VernacularTitle:焦亡在脓毒症中的研究进展
- Author:
Lingzhi SHEN
1
;
Li LI
;
Jing YAN
Author Information
1. 浙江医院重症医学科
- Keywords:
Sepsis;
Pyroptosis;
Inflammation
- From:
Chinese Critical Care Medicine
2019;31(4):498-500
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is an organ dysfunction syndrome caused by an abnormal host immune response because of infection. Pyroptosis is a newly discovered programmed cell death relies on caspase-1, caspase-11, caspase-4, caspase-5 and is characterized by the release of inflammatory cytokines interleukin-1β (IL-1β) and IL-18. The exploration of the molecular mechanisms of pyroptosis and the correlation between pyroptosis and sepsis can provide new ideas and new targets for the treatment of sepsis.
