A Case of Immune Reconstitution Inflammatory Syndrome in AIDS-related Progressive Multifocal Leukoencephalopathy after Antiretroviral Therapy.
- Author:
Sung Hun JU
1
;
Tae Hyung KIM
;
Jung Sik NA
;
Ho Sup SONG
;
In Kyu YU
;
Hee Jung YOON
Author Information
- Publication Type:Case Report
- Keywords: Progressive multifocal leukoencephalopathy; Acquired immunodeficiency syndrome; Highly active antiretroviral therapy; Immune reconstitution inflammatory syndrome
- MeSH: Acquired Immunodeficiency Syndrome; Antiretroviral Therapy, Highly Active; Brain Death; Brain Stem; Central Nervous System; Demyelinating Diseases; Humans; Immune Reconstitution Inflammatory Syndrome; JC Virus; Leukoencephalopathy, Progressive Multifocal; Oligodendroglia; Respiratory Distress Syndrome, Adult
- From:Infection and Chemotherapy 2010;42(3):198-202
- CountryRepublic of Korea
- Language:English
- Abstract: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system due to JC virus. In acquired immunodeficiency syndrome (AIDS) patients, JC virus infects myelin-producing oligodendrocytes causing a non-inflammatory lytic reaction leading to demyelination and brain death. We herein report a case of a 56-years-old AIDS man who developed immune reconstitution inflammatory syndrome and died while undergoing highly active antiretroviral therapy. In this patient, the PML involved the brainstem, causing mental confusion followed by recurrent aspiration, adult respiratory distress syndrome, and eventually to early death.
