Clinical value of Aβ1-42, tau protein and thyroid hormone levels in predicting cognitive impairment after ischemic stroke.
10.3969/j.issn.1002-0152.2019.07.001
- VernacularTitle:血清Aβ1-42、tau蛋白及甲状腺激素水平对缺血性卒中后认知障碍发生的预测价值☆
- Author:
Lei MAO
1
;
Peng LI
;
Xiaohan CHEN
;
Tianjun MA
;
Yixin XU
;
Xiao PAN
;
Jianhua ZHUANG
;
You YIN
Author Information
1. 第二军医大学附属上海长征医院神经内科
- Keywords:
Post-stroke cognitive impairment;
Thyroid hormone level;
β-amyloid protein;
Tau protein
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(7):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum markers β amyloid (Aβ), tau and thyroid hormone levels and post-stroke cognitive impairment (PSCI) in the acute phase of cerebral infarction. Methods A total of 214 patients with acute cerebral infarction were enrolled. The baseline data and serological indicators were collected and the cognitive function of patients was evaluated. All patients were divided into cognitive impairment group and normal group based on follow-up results. The differences of Aβ1-42, tau protein and thyroxine levels between the two groups and their relationship with disease progression were analyzed. The Cox regression analysis and ROC curve were used to compare the above parameters to predict the development of PSCI. Results The total protein level of Tau (210.6 ±98.9 pg/mL) was higher and Aβ1-42 (426.1 ±123.5 pg/mL) and triiodothyronine (T3) (1.43 ±0.57 nmol/L), free thyroxine (FT4) (13.15±2.23 pmol/L) was significantly lower in the cognitive impairment group than in the normal group (P<0.05). Tau protein (r=-0.457), Aβ1-42 (r=0.348), T3 (r=0.211), and FT4 (r=0.306) were all associated with disease progression (P<0.05). Cox regression analysis showed that Aβ1-42 and T3 were important influencing factors in the occurrence of PSCI. The area under the curve of Aβ1-42 combined with T3 was 0.841. The specificity and the sensitivity were 74.8% and 85.3%, respectively, with a diagnostic cutoff value of 0.572. Conclusion Aβ1-42 and T3 levels in the acute phase of cerebral infarction may predict the progression of PSCI.
