Effects of single i.v. subanesthetic dose of ketamine on heart rate, blood pressure and oxygen saturation for antidepressant treatment.
10.3969/j.issn.1002-0152.2019.06.009
- VernacularTitle:单剂氯胺酮抗抑郁治疗对心率、血压和血氧饱和度的影响☆
- Author:
Jiexin FANG
1
;
Le XIAO
;
Xuequan ZHU
;
Gang WANG
;
Ruobing FENG
;
Yongdong. HU
Author Information
1. 首都医科大学附属北京朝阳医院临床心理科(北京100020)
- Keywords:
Ketamine;
Depressive disorder;
Safety
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(6):361-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of single i.v. subanesthetic dose of ketamine on heart rate, blood pressure and oxygen saturation for antidepressant treatment. Methods Patients with severe depressive disorder were randomized to ketamine group (n=13) and control group (n=14). Ketamine group received ketamine (0.5mg/kg) single injection whereas control group received saline single injection. Escitalopram (10 mg/d) were orally administered for 4 weeks simultaneously. Comparisons were made on the heart rate, blood pressure and oxygen saturation at baseline, 40 min, 100 min, and 280 min after injection between the two groups. Results The main effects of time but not group were significant for all parameters including heart rate, systolic blood pressure and diastolic blood pressure, (P＜0.05). Interaction of time×group was significant (P＜0.05). All parameters including heart rate (F=16.85, P＜0.01), systolic blood pressure (F=15.82, P＜0.01) and diastolic blood pressure (F=8.63, P＜0.01) with time were significant in ketamine group. The heart rate, systolic blood pressure and diastolic blood pressure in ketamine group were significantly higher at 40 min than at other time points (P＜0.05), while were no significant difference among other time points (P＞0.05). There was no statistical significance of main effect of time, group and interaction of time×group in oxygen saturation between the two groups (P＞0.05). Conclusion Single subanesthetic dose ketamine intravenous drip for antidepressant therapy may cause a transient increase in heart rate and blood pressure.
