Association analysis of PPP1R3A gene polymorphism with schizophrenia in Uygur Chinese population.
10.3969/j.issn.1002-0152.2019.06.008
- VernacularTitle:PPP1R3A基因多态性与中国维吾尔族人群精神分裂症关联性研究☆
- Author:
Xinyu SHI
1
;
Zhiguo AN
;
Lele SUN
;
Bin XU
;
Daibin MU
;
Songnian FU
;
Hongxing HU
;
Xiao LUO
;
Wen DU
;
Ping YAN
;
Lu JIN
;
Dan NIE
;
Limu-Ershaer-Ai KAO
;
Yongyong SHI
;
Qingzhong. YI
Author Information
1. 新疆医科大学第一附属医院心理医学中心(乌鲁木齐830054)
- Keywords:
Schizophrenia;
PPP1R3A;
Targeted capture;
Association study
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(6):356-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between exon region polymorphism of PPP1R3A gene and schizophrenia in Uygur Chinese population. Methods PPP1R3A gene exon region DNA amplification was performed using multiple PCR targeted capture next-generation sequencing method in 528 patients with schizophrenia and 576 healthy controls of Uyghur descent, Illumina HiSeq X Ten was used for sequencing, the symptoms of schizophrenia were assessed by positive and negative symptoms scale (PANSS). Results The allelic and genotypic distributions in rs1800000 of PPP1R3A gene between patients with schizophrenia and healthy controls had significant difference (P＜0.05), rs1799999 in genotype frequency between the female case and control groups showed significant difference (P＜0.05). Furthermore, the allelic distributions of rs8192686 between male cases and controls had significant difference (P＜0.05). Conclusion PPP1R3A gene rs1800000 may be associated with the development of schizophrenia in Uygur Chinese population; rs1799999 may be a risk factor for susceptibility of female Uygur Chinese schizophrenia; The C allele at rs8192686 may be associated with male Uygur Chinese schizophrenia.
