StudyoncognitiveimpairmentandriskfactorsinpatientswithWilsondisease.
10.3969/j.issn.1002-0152.2019.06.001
- VernacularTitle:Wilson病患者认知功能障碍及其危险因素☆
- Author:
Gongqiang WANG
1
;
Kang LIN
;
Xinfeng MA
;
Shijing WANG
;
Lisheng LIU
;
Yongzhu HAN
;
Renmin. YANG
Author Information
1. 安徽中医药大学神经病学研究所附属医院神经内科(合肥230061)
- Keywords:
Wilson disease;
Hepatolenticular degeneration;
Cognitive impairment;
Risk factors
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(6):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore cognitive impairment and related factors in patients with Wilson disease (WD) and to screen the risk factors of cognitive impairment in order to provide evidence for clinical intervention. Methods The Chinese Version Addenbrooke＇s Cognitive Examination-III (ACE-III-C) was used to assess the cognitive function. The WD patients with cognitive impairment were analyzed the difference between those with non-cognitive disorders in the Young scale, Baethel scale and biochemical indicators. Risk factors for cognitive impairment in WD patients were analyzed by multiple linear regression. Results Cognitive impairment occurred in 43 (59.7%) of 72 patients with WD. ACE-III-C total score, attention, memory, language fluency, visual spatial factor scores, Young scores, Barthel scores and serum copper levels were significantly different between patients with cognitive impairment and patients with non-cognitive impairment (P＜0.01). Linear regression analysis showed that serum copper levels were the most important risk factors for ACE-III-C total score and cognitive subfields (P＜0.01). Serum zinc levels as a secondary risk factor of language fluency and visual space (P＜0.05). Age-related participation affected language fluency (P＜0.05). Conclusions Serum copper and zinc levels may be the main risk factors of cognitive impairment. Modulation of serum copper and zinc levels may be the key for intervention to treat cognitive impairment in WD patients.
