The relationship between the severity of insomnia and the curative effect in acute stage in patients with major depressive disorder.
10.3969/j.issn.1002－0152.2019.04.008
- VernacularTitle:重性抑郁障碍患者失眠严重程度与急性期疗效相关性研究☆
- Author:
Lifei CAI
1
;
Jihui YUE
;
Hong WANG
;
Xuejiao HOU
;
Yanzhi ZENG
;
Shenglin. WEN
Author Information
1. 广东省人民医院
- Keywords:
Major depressive disorder;
Degree of insomnia;
The acute phase;
Clinical curative effect
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(4):228-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the severity of insomnia and the curative effect in acute stage in patients with major depressive disorder (MDD). Methods The Insomnia Severity Index (ISI) was used to evaluate and group the severity of insomnia in the 57 patients with MDD. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. The 24－item Hamilton Depression Scale (HAMD24) was used to evaluate depressive symptoms, and the effect of acute stage (4～6 weeks) was evaluated with its reduction rate. The difference of curative effect was compared among patients with different insomnia levels. Results There was a significantly different recovery rate in acute stage in 3 groups of patients with mild, moderate and severe insomnia ( X2=22.34,P＜0.01). The severity of insomnia in patients with MDD (PSQI) was negatively correlated with the curative effect of acute stage (r=－0.44,P＜0.01). The total score, anxiety/somatization factor score, retardant factor score and despair factor score were significantly higher in severe insomnia group than in the moderate and mild insomnia groups after acute treatment (P＜0.01). Conclusion The severity of insomnia in patients with MDD can predict the curative effect in acute stage. The depressive patients with severe insomnia have residual anxiety/somatization, retardant, feelings of despair and other symptoms more obvious than mild and moderate insomnia patients after acute treatment.
