Interhemispheric functional connectivity in patients with positive symptoms of schizophrenia: a resting-state functional magnetic resonance imaging study.

VernacularTitle:阳性症状为主型精神分裂症脑半球间功能连接的静息态功能MRI研究
Author: Shaojuan QIU ¹ ; Zhangzhang QI ; Guanmao CHEN ; Lian-Ping ZHAO ; Hui ZHAO ; Yanbin JIA ; Shuming ZHONG ; Yao SUN ; Li HUANG ; Ying. WANG
Author Information

1. 暨南大学附属第一医院影像中心(广州 510630)
Keywords: Schizophrenia; Magnetic resonance imaging; Brain function; Voxel-mirrored homotopic connectivity
From: Chinese Journal of Nervous and Mental Diseases 2019;45(3):155-160
CountryChina
Language:Chinese
Abstract: Objective To investigate functional connectivity between the two hemispheres in patients with positive symptoms of schizophrenia using voxel-mirrored homotopic connectivity ( VMHC ) based on resting-state functional magnetic resonance imaging (rs-fMRI). Methods Eighteen patients with positive symptoms of schizophrenia and 22 healthy controls underwent the rs-fMRI. The whole brain VMHC was calculated in order to provide imaging basis for the study of the pathological mechanism of schizophrenia. Results Compared to the controls, VMHC values were decreased in the bilateral orbitofrontal cortex (t=-5.31, P<0.01), fusiform gyrus (t=-5.16, P<0.01), middle occipital gyrus (t=-5.31, P<0.01) in patients with positive symptoms of schizophrenia. Conclusion The functional coordination between homotopic brain regions is impaired in patients with positive symptoms of schizophrenia .