Study on event-related potential of obsessive-compulsive disorder cognitive flexibility.

VernacularTitle:强迫症认知灵活性的事件相关电位研究☆
Author: Qianqian WU ¹ ; Chunyan ZHU ; Fengqiong YU ; Pengjiao SUI ; Lei ZHANG ; Yudan LUO ; Yi DONG ; Kai. WANG
Author Information

1. 安徽医科大学精神医学中心(合肥 230032)
Keywords: Obsessive-compulsive disorder; Cognitive inflexibility; Event Related Potentials (ERPs)
From: Chinese Journal of Nervous and Mental Diseases 2019;45(2):86-90
CountryChina
Language:Chinese
Abstract: Objective To explore the cognitive process of cognitive flexibility in obsessive-compulsive disorder patients. Methods Thirty-two patients with obsessive-compulsive disorder (OCD) and thirty-two healthy controls were included. The Task Switch paradigm and event-related potentials were used to assess cognitive flexibility. Results The accuracy rate was lower in the OCD than in control group in both repeat and switch trials (P＜0.05). Reaction time analysis revealed significant differences in both repeat and switch between the OCD and controls ( P＜0.05). ERPs revealed significant differences in N2 and P3 amplitudes between OCD and controls (P＜0.05). There was no significant correlation between cognitive flexibility (accuracy rate and reaction time of repeat and switch, and N1, N2 and P3 amplitudes) and clinical forced symptoms in OCD (P＞0.05). Conclusion Obsessive-compulsive disorder of cognitive flexibility by injured.