High-throughput sequencing analysis of gut microbiota in patients with schizophrenia in the stage of onset and remission.
10.3969/j.issn.1002-0152.2018.12.001
- VernacularTitle:精神分裂症发作期与缓解期肠道菌群高通量测序分析☆
- Author:
Yanwu ZHANG
1
;
Lijun BAI
;
Qiang CHENG
;
Xulai ZHANG
;
Jiaojiao GAO
;
Jun DUAN
;
Zihan XU
;
Weizhuo YI
;
Rubing PAN
;
Qiannan WEI
;
Hong. SU
Author Information
1. 安徽医科大学公共卫生学院流行病与卫生统计学系
- Keywords:
Schizophrenia;
Feces;
Enteric;
Bacteria
- From:
Chinese Journal of Nervous and Mental Diseases
2018;44(12):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of gut microbiota in patients with schizophrenia between onset and remission. Methods Twelve patients with schizophrenia in the stage of onset were selected as the episode group. Thirteen gender-, age-and BMI-matched patients with schizophrenia during the remission period were selected as the control group. The fecal specimens of the two groups were collected for high-throughput sequencing of the 16S rRNA gene, and the gut microbiota differences between the two groups were analyzed. Results The chao index and ace index of gut microbiota was lower in the episode group than in the control group (t=2.385,P=0.026; t=3.068,P=0.005). The relative abundance of Bacteroides was higher and the relative abundance of Prevotella was lower in the episodes group than in the control group (Z=-2.013, P =0.044; Z=-3.427, P=0.001). The relative abundance of the Prevotella was negatively correlated with the PANSS score (r=-0.577, P=0.003). Conclusion Schizophrenia in the stage of acute episode have altered gut microbiota compared with those in the stage of remission and the gut microbiota is significantly corrected with mental symptoms.
