Relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features
10.3760/cma.j.issn.1674-635X.2019.03.003
- VernacularTitle:MTNR1B基因DNA甲基化与妊娠期糖尿病及妊娠期间糖脂代谢关系的研究
- Author:
Jiapei LI
1
;
Weigang ZHAO
;
Yong FU
;
Yingyue DONG
;
Juan LI
;
Juntao LIU
Author Information
1. 100730,中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室
- Keywords:
MTNR1B DNA methylation;
Gestational diabetes mellitus;
Gestational glucose and lipid metabolism
- From:
Chinese Journal of Clinical Nutrition
2019;27(3):138-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of MTNR1B DNA methylation with gestational diabetes and gestational glucose and lipid metabolism features.Methods 50 patients with gestational hyperglycemia,diagnosed by 100 g oral glucose tolerance test (OGTT) during mid-trimester were selected between 2009 and 2012.50 pregnant women with normal glucose tolkerance of matched age and body mass index were included in the control group.The blood samples during mid-trimester and the clinical parameters were collected.MTNR1B DNA methylation levels were measured.Results After adjusting age and body mass index,the CpG locus located at +64 bp away from the translation initiation site of MTNR1B was related with gestational diabetes (OR=0.859,95％ CI:0.772-0.955,P=0.005).DNA methylation level of several MTNR1B loci was also related with gestational glucose and lipid metabolism features.Conclusion MTNR1B DNA methylation is related with gestational diabetes and gestational glucose and lipid metabolism.
