Clinical distribution and antibiotic resistance profile of the bacterial strains isolated from blood culture in People's Hospital of Inner Mangolia Autonomous Region during the period from 2012 to 2017
10.16718/j.1009-7708.2018.06.014
- VernacularTitle:2012-2017年内蒙古自治区人民医院血培养分离菌的临床分布及耐药性分析
- Author:
Ya'nan ZHAO
1
;
Jianping ZHAO
Author Information
1. 内蒙古医科大学内蒙古临床医学院
- Keywords:
bloodstream infection;
pathogenic bacteria;
clinical distribution;
antibiotic resistance
- From:
Chinese Journal of Infection and Chemotherapy
2018;18(6):641-645
- CountryChina
- Language:Chinese
-
Abstract:
Objective The distribution of pathogenic bacteria and antibiotic resistance was studied in the People's Hospital of Inner Mongolia Autonomous Region from January 2012 to December 2017 for rational antimicrobial therapy and control of bloodstream infections. Methods A retrospective analysis was conducted on the pathogenic strains of bloodstream infection. A total of 2 095 strains were collected and subjected to identification by Bact/ALERT 3D automatic blood culture instrument and VITEK 32 automatic microbiological analysis and susceptibility testing. The data were analyzed by using WHONET 5.6 software and SPSS 22.0 software. Results Of the 2 095 strains of pathogens, gram negative bacteria accounted for 50.1％ and gram-positive bacteriaaccounted for 49.9％. Specifically, the top species included coagulase negative Staphylococcus (34.8％), Escherichia coli (27.8％), Klebsiella pneumoniae (9.1％), Staphylococcus aureus (6.9％), and Enterococcus (6.6％). These strains were mainly identified from ICU (22.5％) and general surgery department (9.3％). The prevalence of methicillin-resistant coagulase negative Staphylococcus (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) was 82.3％ and 44.8％, respectively. No gram-positive bacteria were resistant to vancomycin and linezolid. The E. faecium strains showed higher resistance rates to common antimicrobial agents than E. faecalis strains. Enterobacteriaceae species including E. coli, K. pneumoniae, and E. cloacae were highly resistant to ampicillin (＞80％). The resistance rate of Enterobacteriaceae species to imipenem, meropenem, amikacin, and piperacillin-tazobactam was lower than 9.4％. In the non-fermentative bacteria, Acinetobacter baumannii strains were highly resistant to multiple antimicrobial agents except amikacin (22.2％). Conclusions The pathogenic bacteria of bloodstream infection are complex, consisting of similar proportion of gram-positive bacteria and gram-negative bacteria. The pathogens were mainly found in ICU. Antibiotic-resistant strains identified are highly resistant to multiple antimicrobial agents. Efforts should be made to strengthen antimicrobial resistance surveillance for rational antimicrobial therapy.
