Surveillance of antimicrobial resistance in Peking Union Medical College Hospital in 2017
10.16718/j.1009-7708.2018.06.010
- VernacularTitle:2017年北京协和医院细菌耐药性监测
- Author:
Wenjing LIU
1
;
Yingchun XU
;
Qiwen YANG
;
Yao WANG
;
He WANG
;
Hongli SUN
;
Ying ZHAO
;
Yali LIU
;
Lina GUO
;
Hongtao DOU
;
Renyuan ZHU
;
Li ZHANG
;
Meng XIAO
;
Xiaojiang ZHANG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院检验科
- Keywords:
antimicrobial resistance surveillance;
antimicrobial agent;
extensively drug-resistant bacteria;
antimicrobial susceptibility testing
- From:
Chinese Journal of Infection and Chemotherapy
2018;18(6):614-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antimicrobial resistance of clinical bacterial isolates in Peking Union Medical College Hospital (PUMCH) in 2017. Methods A total of 9 515 non-duplicate clinical isolates were collected from January 1 to December 31, 2017. Disc diffusion test (Kirby-Bauer method) and E-test method were employed to determine antimicrobial susceptibility. Results Gram-negative bacilli and gram-positive cocci accounted for 68.2％ and 31.8％, respectively among the 9 515 clinical isolates. Methicillin-resistant strains in S. aureus (MRSA) and coagulase-negative Staphylococcus (MRCNS) accounted for 25.6％ and 73.3％, respectively. Extended-spectrum β-lactamases (ESBLs) -producing strains accounted for 47.6％ (877/1 842), 27.6％ (335/1 213) and 33.0％ (59/179) in E. coli, Klebsiella spp (K. pneumoniae and K. oxytoca) and P. mirabilis, respectively. Enterbacteriaceae strains were still highly susceptible to carbapenems, with an overall resistance rate of ≤ 3.8％. The resistance rates of K. pneumoniae to imipenem and meropenem were 8.5％ and 8.2％, respectively. About 72.7％ and 70.4％ of A. baumannii isolateswere resistant to imipenem and meropenem. The resistance rate of P. aeruginosa to imipenem and meropenem was 14.8％ and 10.0％, respectively. The prevalence of extensively drug-resistant strains in A. baumannii, P. aeruginosa and K. pneumoniae was 31.7％ (239/753), 1.0％ (10/1 035), and 3.0％ (33/1 117), respectively. Conclusions The common bacterialisolates show various level of resistance to antimicrobial agents. Laboratory staff should improve communication with clinicians to prevent the spread of resistant strains.
