Advances in fluorosis-induced nervous system injury and antagonistic protection
10.3760/cma.j.issn.2095-4255.2019.07.019
- VernacularTitle:氟中毒性神经损伤与拮抗保护的研究进展
- Author:
Yitong ZHANG
1
;
Zhongling ZHANG
Author Information
1. 哈尔滨医科大学附属第一医院神经内科 150001
- Keywords:
Fluorosis;
Nervous system;
Black garlic;
Oxidative stress
- From:
Chinese Journal of Endemiology
2019;38(7):597-602
- CountryChina
- Language:Chinese
-
Abstract:
The damage of nervous system caused by fluorosis has been paid more and more attention. Fluorosis can lead to memory loss, mental retardation and cognitive deficits in children. Advance in the understanding of the mechanism of fluorosis induced nervous system damage will be summarized here from several aspects, including oxidative stress, signal transduction and neurotransmitters and receptors. Oxidative stress is the central link in the mechanism of fluorotoxic nerve damage. Studies have suggested that in addition to some antioxidant drugs and preparations, black garlic, which is a food, has many biological effects such as antioxidants. It suggested that black garlic may have protective effects on fluorosis nerve injury through analyzing the antioxidant property and neuroprotective effects of black garlic, further studies are needed to address the effect and the underlying mechanism of black garlic.
