Observation of prolactin and estradiol levels in lactating women in different iodine nutrition areas
10.3760/cma.j.issn.2095-4255.2019.05.008
- VernacularTitle:不同碘营养地区哺乳妇女催乳素和雌二醇水平观察
- Author:
Baiming JIN
1
;
Siyuan WAN
;
Hongmei SHEN
;
Lixiang LIU
;
Fangang MENG
;
Xiaoye ZHANG
Author Information
1. 齐齐哈尔医学院公共卫生学院预防医学教研室
- Keywords:
Iodine;
Lactating women;
Prolactin;
Estradiol
- From:
Chinese Journal of Endemiology
2019;38(5):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe prolactin (PRL) and estradiol (E2) levels in lactating women in different iodine nutrition areas.Methods According to the recent national water-borne high iodine area survey and the monitoring results of iodine deficiency disorders,the following places were selected,including Nankang,Xinggang and Yingpan towns of Beihai City,Guangxi (water iodine ≤ 10 μg/L,low iodine areas),Yangcheng Township and Jiajiazhuang Township of Fenyang City,Shanxi (water iodine 50-100 μg/L,adaptive iodine areas),Pingyao County and Jicun Town of Fenyang City,Shanxi (water iodine ≥300 μg/L,high iodine areas),and urinary and blood samples were collected in lactating women (n =100,97,123) from the three regions.The urinary iodine concentration was tested by arsenic cerium catalytic spectrophotometry.Serum levels of PRL and E2 were determined by chemiluminescence immunoassay.Results The urinary iodine medians of lactating women were 51.42,283.62,842.31 μg/L,respectively,in the three regions,the difference between the regions was statistically significant (x2 =241.09,P ＜ 0.05);the iodine levels of lactating women in low iodine areas,adaptive iodine areas and high iodine areas were in the state of iodine deficiency (＜ 100 μg/L),sufficient or adequate (200-299 μg/L) and iodine excess status (≥ 300 μg/L),respectively.Serum PRL and E2 levels of lactating women in the three types of areas were 38.81,20.98,16.41 μg/L and 29.57,43.70,45.51 ng/L,respectively.The differences between the regions were statistically significant (x2 =41.54,24.03,P ＜ 0.05).Conclusion With the increase of iodine nutrition level,PRL in lactating women has presented a gradually decreasing trend,E2 is increased.
