The value of combined detection of sFIt-1, PLGF and Survivin in the diagnosis of early-onset preeclampsia
10.3760/cma.j.issn.1673-4904.2019.08.015
- VernacularTitle:联合检测血清中可溶性血管内皮生长因子受体-1、胎盘生长因子、Survivin表达水平在早发型子痫前期诊断中的价值研究
- Author:
Jinheng ZHAO
1
;
Qian WANG
;
Xuemei SANG
;
Yixin JIA
;
Guixin ZHANG
;
Lijun SUN
Author Information
1. 唐山市妇幼保健院妇产科 063000
- Keywords:
Serum;
sFIt-1;
PLGF;
Early onset preeclampsia
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(8):727-730
- CountryChina
- Language:Chinese
-
Abstract:
s] Objective To analyze the diagnostic value of combined detection of sFIt-1, PLGF and Survivin in early onset preeclampsia. Methods From January 2017 to January 2018, 100 patients with early-onset PE were selected as observation group and 100 healthy pregnant women as control group in Tangshan Maternal and Child health Hospital Gynecology and Obstetrics. The expression levels of sFIt-1, PLGF and Survivin in serum were detected by enzyme-linked immunosorbent assay (ELISA), and the diagnostic value of each index was analyzed separately and jointly. Results The levels of sFIt-1 in the observation group were significantly higher than those in the control group: (36.58 ± 18.34) μg/L vs. (28.43 ± 3.28) μg/L (P<0.05), and the levels of PLGF and Survivin in the observation group were significantly lower than those in the control group: (213.18 ± 48.23) ng/L vs. (398.17 ± 41.19) ng/L, (0.72 ± 0.29) μg/L vs. (1.43 ± 0.32) μg/L (P<0.05); 103 cases of positive sFIt-1, 108 cases of positive PLGF, 107 cases of positive Survivin, 121 cases of positive parallel combined diagnosis and 121 cases of positive series combined diagnosis were found. The sensitivity and negative predictive value of parallel combined diagnosis were significantly higher than those of individualized diagnosis (P<0.05), and the specificity and positive predictive value of series combined diagnosis were significantly higher than those of individualized diagnosis (P < 0.05). Conclusions The combined detection of sFIt-1, PLGF and Survivin in serum can effectively improve the diagnostic accuracy of early-onset preeclampsia and has high clinical value.
