Threshold analysis of extent of resection for patients with gradeⅢgliomas using MRI
10.3760/cma.j.issn.1673-4904.2019.08.014
- VernacularTitle:Ⅲ级胶质瘤MRI切除程度阈值的研究
- Author:
Xiaozhen ZHAN
1
;
Kai XU
;
Jiyong LENG
;
Weidong WU
;
Peiyu CONG
Author Information
1. 大连医科大学附属大连市中心医院神经外科 116033
- Keywords:
Glioma;
Extent of resection;
Prognosis;
Overall survival
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(8):723-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic significance of extent of resection (EOR) in patients with gradeⅢglioma, and the MRI sequence best related with tumor volume. Methods Ninety-six cases were studied retrospectively who were diagnosed as glioma of grade Ⅲ gliomas at Dalian Medical University Affiliated Hospital of Dalian Municipal Central Hospital during the period from 2010 to 2015. EOR was calculated using preoperative and postoperative contrast-enhanced T1-weighted and T2-weightedfluid attenuated inversion recovery (T2Flair) MR images. Univariate and multivariate analyses were performed to evaluate the correlation between EOR and overall survival (OS). Results The results of univariate analysis showed that patients with age<50 years(P=0.032), preoperative KPS>80 scores (P<0.01), no edema (P=0.005), postoperative chemotherapy (P<0.01) and T2Flair EOR≥68% (P<0.01) had better prognosis. Cox multivariate regression analysis showed that age(P=0.008), edema (P＝0.003), postoperative chemotherapy(P=0.000) and T2Flair EOR (P=0.004) were independent factors of prognosis for grade Ⅲ glioma patients. Conclusions T2Flair-EOR is one of the most significant prognostic predictors in patients with grade Ⅲ gliomas. An important survival advantage is associated with T2Flair-EOR≥68% for patients with gradeⅢgliomas.
